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Scholarly Gluten-Related Articles

Posted by nepeht on November 29, 2008

This is an evolving anotated bibliography of scholarly articles related to Gluten-Sensititivity and its related diseases and disorders.  If you have an article to suggest for inclusion please do so with a Comment. 

Coeliac Disease and Gluten-Free Diet:

“Coeliac patients improve vastly when started on a gluten-free diet. After 10 years, however, women show a lower level of subjective health than men do.”  Living with Coeliac Disease: Controlled Study of the Burden of Illness
Authors: Hallert C.; Grännö C.; Hultén S.; Midhagen G.; Ström M.; Svensson H.; Valdimarsson T.  Source: Scandinavian Journal of Gastroenterology, Volume 37, Number 1, 1 January 2002 , pp. 39-42(4).


Relationship between Chronic Schizophrenia and Celiac Disease:

“A possible association between gluten consumption and schizophrenia has been reported.”

“In contrast to previous reports, we found no evidence for celiac disease in patients with chronic schizophrenia as manifested by the presence of serum IgA anti-endomysial antibodies. It is unlikely that there is an association between gluten sensitivity and schizophrenia.”

 Roni Peleg, , a, Z. Itzhak Ben-Zionb, Aya Pelegc, Larisa Gheberd, e, Moshe Kotlerf, Zvi Weizmang, Asher Shiberb, Alex Fichd, Yael Horowitza and Pesach Shvartzmana.
“Bread madness” revisited: screening for specific celiac antibodies among schizophrenia patients. European Psychiatry. Volume 19, Issue 5, August 2004, Pages 311-314.


 Affective Disorders, quality of life and celiac Disease

“In coeliac disease, affective disorders should be ascribed to difficulties in adjusting to the chronic nature of the disease rather than directly to the disease itself, thus giving an indication for preventive liaison psychiatric interventions.”

Affective disorders and quality of life in adult coeliac disease patients on a gluten-free diet.  Fera, Tiziana a; Cascio, Barbara a; Angelini, Guiseppe a; Martini, Silvia b; Guidetti, Carla Sategna b. (2003). European Journal of Gastroenterology & Hepatology. 15(12):1287-1292, December 2003.


Gluten Sensitivity in Areas other than the Gut

M Hadjivassiliou, R A Grünewald, & G A B Davies-Jones, Consultant neurologist. (1999). (Editorial). Gluten sensitivity: a many headed hydra Heightened responsiveness to gluten is not confined to the gut. BMJ 1999;318:1710-1711 (26 June).


Gluten and Schizophrenia

“Schizophrenics maintained on a cereal grain-free and milk-free diet and receiving optimal treatment with neuropleptics showed an interruption or reversal of their therapeutic progress during a period of “blind” wheat gluten challenge. The exacerbation of the disease process was not due to variations in neuroleptic doses. After termination of the gluten challenge, the course of improvement was reinstated. The observed effects seemed to be due to a primary schizophrenia-promoting effect of wheat gluten.”

MM Singh and Kay SR. (1976). Wheat gluten as a pathogenic factor in schizophrenia. Science, Vol 191, Issue 4225, 401-402.


Psychiatric Support and Gluten-Free Diet Compliance

“In coeliac disease patients with affective disorders psychological support seems to be able to reduce depression and to increase gluten-free diet compliance.”  

G. Addolorato, G. De Lorenzi, L. Abenavoli, L. Leggio, E. Capristo & G. Gasbarrini. (2004). Psychological support counselling improves gluten-free diet compliance in coeliac patients with affective disorders. Alimentary Pharmacology & Therapeutics. Volume 20 Issue 7, Pages 777 – 782. Published Online: 8 Sep 2004.


Psychotic Disorders and Gluten

“The authors speculate that gluten may be involved in biological processes in the brain in certain psychotic individuals.” A Ashkenazi, D Krasilowsky, S Levin, D Idar, M Kalian, A Or, Y Ginat and B Halperin. Immunologic reaction of psychotic patients to fractions of gluten.
(1979). Am J Psychiatry 1979; 136:1306-1309.


Sharing life with a gluten-intolerant person–the perspective of close relatives.

“Several studies indicate the importance of social support in the case of chronic disease. AIM: The aim was to explore dilemmas experienced by close relatives living with a person suffering from coeliac disease, and to describe the strategies they used to deal with these dilemmas.”
“Close relatives experienced a variety of dilemmas that affected the situation of the whole family. The role of relatives in handling the coeliac disease with the diseased person in the everyday life might be underestimated, and to provide relatives with better knowledge regarding the disease might improve the situation also for patients.”  Sverker A, Ostlund G, Hallert C, Hensing G. (2007). Sharing Life with a gluten-intolerant person. J Hum Nutr Diet. 2007 Oct;20(5):412-22. 


The Gluten-Free Diet: Hot To Provide Effective Education and Resources. Gastroenterology. 2005 Apr;128(4 Suppl 1):S128-34. Case, C.


Epidemiology of Celiac Disease

Marian Rewers. (2005). Epidemiology of celiac disease: What are the prevalence, incidence, and progression of celiac disease? Volume 128, Issue 4, Supplement 1, April 2005, Pages S47-S51.


Celiac Disease and Pedicatrics

 “Because CD often is atypical or even clinically silent, many cases go undiagnosed and are exposed to the risk of long-term complications. There is growing interest in the social aspects of CD because the burden of illness related to this condition is doubtless higher than previously thought.”
Fasano, A. (2005). Clinical presentation of celiac disease in the pediatric population. Volume 128, Issue 4, Supplement 1, Pages S68-S73 (April 2005).


Genetics and Epidemiology of Celiac Disease

Genetics and Epidemiology of Celiac Disease
Alessio Fasano, M.D.
“CD is one of the most common lifelong disorders in Europe and in the US. This condition
can manifest with a previously unsuspected range of clinical presentations.” (p.2).
“In countries where individuals are mostly of European origin, the prevalence of CD ranges
between 0.25 and 1 % in the general population (3-5).”
“The treatment of CD is based on the lifelong exclusion of gluten-containing cereals from the
diet. In most developed countries this is easily accomplished by using both cereals that do not
contain gluten (e.g. rice and maize) and palatable gluten-free, commercially available, products
which are specifically manufactured for celiac patients. In contrast, treating CD in a poor context of
life appears to be an exceptionally hard task. The situation is more and more complex, since the
consumption of wheat is increasing in many developing countries that tend to adopt the “western”
dietary style. An international cooperation is required to implement the possibility of diagnosing
and treating CD in the developing world.”

Stress and Relapse with Addiction,-Fundraising,-Epidemiology,-Etc./.


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Participating in Celiac- or Gluten-Related Research

Posted by nepeht on November 4, 2008

  Ever considered participating in Celiac- or Gluten-Related Research?  Are you interested in doing so?

  If you are or have been involved in clinical research, this might be old news to you.  If not, you might find this helpful.   For an example of some Celiac Disease related research one can go to:,-Fundraising,-Epidemiology,-Etc./

  As a professional researcher, but one who is NOT currently involved in any way in any Celiac- or Gluten-Related research, I can say two things up front:

  1. Competent and safe research regarding Celiac- or Gluten-Related phenomena is extremely important to those who are not perfectly OK with having Celiac Disease or another condition negatively responsive to Gluten Exposure.  Mostly, it is important for those who are either younger than us or those who cannot now advocate for themselves.  And participation in such research is crucial to its success.
  2. Secondly, I need to say that I can in no way endorse or criticize any of the research projects that I might tell you about in this blog.

  All that being said…  The NIH (National Institutes of Health) has a list of currently about 26 related studies, many of which are recruiting for participants.  One may or may not be eligible for participation and may or may not be compensated.  You can view the list at the following link:

  If you have ir are interested in other health conditions and you might consider participating, the following link provides search capabilities:

  This link leads to studies related to Crohn’s disease:

  There are probably many other studies one could get involved in.  At first though, I just wanted to list the NIH-related studies because I have confidence that researchers who comply with this organization have the least likelihood of putting human participants at risk.

  If you are interested in reports and updates on Celiac Disease research, you can got to the following sites:

  Go ahead, search for yourself.  You might find this information interesting and useful.  You might even discover a constructive way to get involved in this typically good work.

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